The Park has very
rich flora and fauna. Over 93 species of mammals, about 300 species of
birds, 9 amphibian, 33 reptilian and several insectivorous species, and
56 endemic butterfly species have been recorded

i) Species of Conservation and Tourist Interest in Mole
Mole National Park has over 90 species of mammals.  Elephant, buffalo, kob, warthog, waterbuck, bushbuck, roan antelope, hartebeest, duikers, oribi, patas monkey and green (vervet) monkey are the species commonly seen at Mole National Park. Aerial surveys of the large mammals have been carried out between 1993 and 2006. Predators in the Park include spotted hyenas, leopards, caracal, civets, genets, jackals and mongooses. Even though there are lions in the park, their population and home range has declined, making their presence and sighting rare.

ii) Endangered Species
The lions (pantheraleo) and elephants (laxodonta Africana) found in Mole National Park are currently listed as vulnerable on the IUCN red list of 2004. The spotted hyena, buffalo, oribi, roan antelope, kob, duiker and reedbuck are listed as lower risk on the same publication. These species require particular management to thrive.

iii) Birds
Studies have been made of the avian life in Mole National Park, and a full report can be consulted (Dowsett, 2005). Over 300 bird species have been recorded, many of which are migratory birds heading to or from Northern Europe. The Carmine bee-eater and Saddle-billed stork are particularly stunning, and all will appreciate their beauty!
Mole is unique in its bird populations: all 37 recorded Guinea-Sudanian biome species found in Ghana are here in the National Park. If you are a keen bird watcher, Mole is a must! As well as the species mentioned earlier, you are almost guaranteed sightings of martial eagles, the white-headed and palm-nut vultures, herons, egrets, the Abyssinian roller, the violet turaco and the red-throated bee-eater, to name a few.

iv) Reptiles
There are 33 reptile species in the Park. The Nile crocodile, slender snouted crocodile and dwarf crocodile can be seen in the rivers within the Park.

v) Butterflies
More than 50 butterfly species have been spotted in Mole National Park, including the Anthenetalboti, which is usually limited to East Africa. Mole is the only part of West Africa where this species has been recorded.
The total butterfly fauna is probably about 120. Most are typical of the Guinea savannah belt. Two species of Euphaedra were found: the genus is mainly one of the understorey of true evergreen forest, but the two species in question seem well established in dense woodland in the park.
The West African savannah habitats are generally not species rich, and there is virtually no endemism. True savannah butterflies constitute about 15% of the total Ghana butterfly fauna of more than 900 species. The best season for butterfly studies in Mole is between late May and early June.